Scott L Friedman Selected Research

Kruppel-Like Factor 6

2/2013	Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury.
9/2012	Hepatocyte growth factor enhances alternative splicing of the Kruppel-like factor 6 (KLF6) tumor suppressor to promote growth through SRSF1.
3/2010	Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.
3/2009	Functional role of the KLF6 tumour suppressor gene in gastric cancer.
8/2008	KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.
7/2008	The Kruppel-like factor 6 genotype is associated with fibrosis in nonalcoholic fatty liver disease.
10/2005	Regulation of Kruppel-like factor 6 tumor suppressor activity by acetylation.
11/2004	Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma.
8/2004	Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor 6 (KLF6) tumor suppressor protein: potential interactions between KLF6 and p53.
6/2004	Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.

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Scott L Friedman Research Topics

Disease

91	Fibrosis (Cirrhosis) 01/2022 - 01/2002
48	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 08/2004
46	Neoplasms (Cancer) 11/2021 - 03/2003
31	Liver Diseases (Liver Disease) 10/2021 - 02/2003
29	Hepatocellular Carcinoma (Hepatoma) 11/2021 - 02/2002
22	Inflammation (Inflammations) 10/2021 - 06/2004
20	Non-alcoholic Fatty Liver Disease 01/2022 - 12/2004
11	Infections 01/2020 - 02/2002
8	Cicatrix (Scar) 06/2021 - 07/2002
8	Fatty Liver 06/2021 - 05/2013
8	Necrosis 01/2016 - 12/2004
7	Hepatitis C 07/2014 - 12/2004
6	Carcinogenesis 11/2019 - 01/2005
6	Prostatic Neoplasms (Prostate Cancer) 02/2006 - 04/2004
5	Alcoholic Fatty Liver 10/2021 - 05/2015
5	Liver Neoplasms (Liver Cancer) 12/2016 - 12/2008
3	Disease Progression 01/2018 - 01/2012
3	Chronic Hepatitis C 11/2017 - 08/2007
3	Vascular System Injuries 04/2016 - 04/2009
3	Neoplasm Metastasis (Metastasis) 10/2015 - 03/2003
2	Portal Hypertension 12/2022 - 09/2013
2	Hypoxia (Hypoxemia) 11/2019 - 03/2003
2	Wounds and Injuries (Trauma) 04/2016 - 02/2011
2	Ischemia 01/2016 - 08/2013
2	Reperfusion Injury 01/2016 - 01/2012
2	Weight Loss (Weight Reduction) 01/2016 - 08/2015
2	Hepatitis B 05/2015 - 03/2011
2	Insulin Resistance 05/2013 - 04/2012

Drug/Important Bio-Agent (IBA)

25	Proteins (Proteins, Gene)FDA Link 06/2021 - 07/2002
19	CollagenIBA 01/2022 - 04/2002
17	Pharmaceutical PreparationsIBA 01/2022 - 02/2006
16	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2007
16	Messenger RNA (mRNA)IBA 04/2016 - 03/2003
13	Transcription Factors (Transcription Factor)IBA 01/2020 - 08/2004
11	Carbon Tetrachloride (Tetrachloromethane)IBA 10/2021 - 07/2006
11	Kruppel-Like Factor 6IBA 02/2013 - 04/2004
9	CytokinesIBA 01/2021 - 07/2002
7	Thioacetamide (Thioacetamid)IBA 06/2018 - 08/2006
7	Protein Isoforms (Isoforms)IBA 02/2013 - 02/2005
6	Bile Acids and Salts (Bile Acids)IBA 06/2021 - 04/2013
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2013 - 03/2003
5	MicroRNAs (MicroRNA)IBA 01/2022 - 05/2011
5	CholesterolIBA 11/2021 - 04/2016
5	Antiviral Agents (Antivirals)IBA 01/2021 - 07/2014
5	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 04/2012
5	Transforming Growth Factors (Transforming Growth Factor)IBA 11/2019 - 09/2004
5	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 04/2004
5	Collagen Type I (Type I Collagen)IBA 11/2017 - 03/2007
5	Transforming Growth Factor beta (TGF-beta)IBA 04/2016 - 05/2007
5	Sorafenib (BAY 43-9006)FDA Link 03/2013 - 10/2009
4	Vitamin A (Retinol)FDA LinkGeneric 07/2017 - 04/2004
4	Matrix Metalloproteinases (MMPs)IBA 04/2016 - 09/2010
4	LigandsIBA 05/2015 - 02/2002
4	3,7,11,15- tetramethyl- 2,4,6,10,14- hexadecapentaenoic acidIBA 05/2004 - 11/2002
3	cenicrivirocIBA 01/2022 - 01/2016
3	Interleukin-6 (Interleukin 6)IBA 02/2021 - 04/2005
3	LipidsIBA 11/2020 - 05/2013
3	Extracellular Matrix ProteinsIBA 11/2019 - 10/2015
3	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 11/2019 - 10/2012
3	nasIBA 01/2018 - 04/2013
3	InterferonsIBA 11/2017 - 05/2004
3	Peptide Hydrolases (Proteases)FDA Link 04/2015 - 02/2003
3	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2013 - 02/2002
3	Interleukin-10 (Interleukin 10)IBA 11/2012 - 09/2004
3	Discoidin Domain Receptor 2IBA 10/2012 - 02/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2012 - 02/2007
3	ChemokinesIBA 01/2012 - 08/2010
3	alpha-Fetoproteins (alpha-Fetoprotein)IBA 09/2009 - 04/2004
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2009 - 12/2004
3	Small Interfering RNA (siRNA)IBA 12/2008 - 07/2005
3	Oxidants (Oxidizing Agents)IBA 12/2004 - 01/2002
3	RetinoidsIBA 05/2004 - 11/2002
2	Hormones (Hormone)IBA 11/2021 - 08/2008
2	obeticholic acidIBA 10/2021 - 11/2020
2	Fatty Acids (Saturated Fatty Acids)IBA 10/2021 - 06/2021
2	EnzymesIBA 06/2021 - 04/2013
2	InterleukinsIBA 02/2021 - 11/2012
2	FructoseIBA 11/2020 - 01/2018
2	Interferon-gamma (Interferon, gamma)IBA 11/2019 - 07/2009
2	Urea (Carbamide)FDA LinkGeneric 09/2018 - 01/2016
2	CreatinineIBA 09/2018 - 01/2016
2	Hydroxyproline (4 Hydroxyproline)IBA 09/2018 - 01/2015
2	NitrogenIBA 09/2018 - 01/2016
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 09/2018 - 12/2008
2	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 09/2018 - 07/2015
2	Chemokine ReceptorsIBA 01/2018 - 01/2012
2	IntegrinsIBA 11/2017 - 01/2016
2	Ribavirin (Virazole)FDA LinkGeneric 11/2017 - 08/2007
2	Metalloproteases (Metalloproteinases)IBA 04/2016 - 04/2015
2	EndoglinIBA 04/2016 - 04/2009
2	Activin Receptors (Activin Receptor)IBA 04/2016 - 01/2013
2	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 01/2016 - 09/2012
2	Angiotensin IIIBA 09/2015 - 06/2004
2	Plasma KallikreinIBA 01/2015 - 01/2014

Therapy/Procedure

50	Therapeutics 01/2022 - 02/2003
8	Liver Transplantation 01/2022 - 02/2003
4	Chemoprevention 01/2018 - 04/2004
3	Drug Therapy (Chemotherapy) 01/2021 - 04/2004
3	Bariatric Surgery 01/2018 - 04/2013
3	Ligation 07/2015 - 09/2011